The role of vaccination in patients with autoinflammatory diseases in the era of SARS-CoV-2 pandemic

Despite being safe, sustainable and effective, vaccines account for a trigger inducing systemic inflammation in autoinflammatory diseases. Also, vaccinations could flare up relapses in patients already diagnosed with an autoinflammatory pathological condition or elicit new signs and symptoms of the immune diseases. Therefore, investigation about the possible role of vaccinations in inducing inflammatory events is an unmet need to solve. The AIDA project may represent the right tool to pursue this objective. Therefore, the patient registries dedicated to Systemic Autoinflammatory Diseases could include an instrument aimed at assessing this topic by filling in the following additional variables:

• Whether the vaccination has either induced the disease or flared up new disease manifestations or exacerbations
• If so, the type of vaccine administered
• If COVID19-vaccine, the brand of the vaccine presumed to have induced inflammation
• The date of vaccine administration
• When signs and symptoms of disease have occurred
• The type of signs and symptoms
• Whether new signs and symptoms have occurred after the vaccinations with respect to the plethora of usual clinical and laboratory manifestations
• Whether the supposed vaccination-induced inflammation has solved spontaneously
• Treatment approaches used to solve inflammation and their effectiveness
• Treatments performed at the time of the vaccination