Publications

The AIDA Registries for monogenic and multifactorial autoinflammatory diseases and those for non-infectious uveitis and scleritis have been developed and activated for data sharing, international consultation, and knowledge diffusion. The main reasons for their deployment are to overcome the scientific and clinical fragmentation and to perform solid and pioneering international studies based on wide cohorts of patients and real-world data.

Vitale A, Caggiano V, Sbalchiero J, et al. Long-term remission and monocyclic course in Still’s disease patients starting canakinumab early: data from the international AIDA network registry. Seminars in Arthritis and Rheumatism. Published 20 June 2026. doi: 10.1016/j.semarthrit.2026.153030

Vitale A, Caggiano V, Sbalchiero J, et al. Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry. Front. Immunol. Published 13 May 2026. doi: 10.3389/fimmu.2026.1778171

Sota J, Hinojosa-Azaola A, de-la-Torre A, et al. Determinants of Non-infectious Scleritis Complications and Their Impact on Visual Outcome: Results from the International AIDA Network Scleritis Registry. Ophthalmol Ther. Published 09 May 2026. doi: 10.1007/s40123-026-01390-5

Ruscitti P, Masedu F, Vitale A, et al. Application of machine learning techniques to explore the occurrence of macrophage activation syndrome in Still’s disease: results from the GIRRCS AOSD Study Group and the AIDA Network Still’s Disease Registry. Frontiers in Immunology. Published 14 April 2026. doi: 10.3389/fimmu.2026.1811317

Caggiano V, Sbalchiero J, Frassi M, et al. Recurrent fever and association with severe organ involvement, mortality and treatment outcomes in VEXAS syndrome: data from the AIDA Network. Frontiers in Immunology. Published 13 March 2026. doi: 10.3389/fimmu.2026.1753412

Sevik G, Lopalco G, Iannone F, et al. The use of non-TNF targeted biologics in Behçet’s Disease: Real‐life data from the International AIDA Network Behçet’s Disease Registry. Rheumatology. Published 17 February 2026. doi: 10.1093/rheumatology/keag086

Gavioli F, Caggiano V, Sbalchiero J, et al. VEXAS syndrome and cancer: Insights about a possible “Tip of the Iceberg”. Ambidirectional data from the international AIDA network registries. Seminars in Arthritis and Rheumatism. Published 22 January 2026. doi: 10.1016/j.semarthrit.2026.152932

Caggiano V, Sbalchiero J, Frassi M, et al. Clinical and laboratory markers to distinguish VEXAS from Schnitzler's syndrome: data from the AIDA network registries. Frontiers in Medicine. Published 12 January 2026. doi: 10.3389/fmed.2025.1659758

Gaggiano G, De-La-Torre A, Guerriero S, et al. Reproductive Life Stages and Female Sex-Specific Patterns in Uveitis Activity: Data From the AIDA Network Uveitis Registry. American Journal of Ophthalmology. Published 3 December 2025. doi: 10.1016/j.ajo.2025.11.009

Vitale A, Gavioli F, Caggiano V, et al. Risk of major organ involvement in Behçet’s patients with mucocutaneous onset: data from the AIDA Network Registry. Rheumatology. Published 19 November 2025. doi: 10.1093/rheumatology/keaf613

Vitale A, Caggiano V, Sbalchiero J, et al. The Risk of Developing Ocular Involvement Among Behçet’s Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behçet’s Disease Registry. Ophthalmol Ther. Published 08 November 2025. doi: 10.1007/s40123-025-01258-0

Calabrese L, Cartocci A, Vitale A, et al. IL-1 targeting agents in Schnitzler syndrome: a multicentre, real-world study from the international AIDA Network Schnitzler Registry. Clin Exp Rheumatol. Published 23 October 2025. doi: 10.55563/clinexprheumatol/i9hsfr

Calabrese L, D'Onghia M, Cartocci A, et.al. Unfolding dermatological spectrum of Still’s disease: a cohort study from the International AIDA Network Still’s Disease Registry. Rheumatology. Published 30 September 2025. doi: 10.1093/rheumatology/keaf512

Gaggiano C, De-la-Torre A., Cardona-López J, et.al. Incidence and Predictors of Ocular Complications in Pediatric-Onset Uveitis: Data from the AIDA Network Uveitis Registry. Ophthalmology and Therapy. Published 23 September 2025. doi: 10.1007/s40123-025-01237-5

Di Meglio N, Sica C, Vitale A, et. al. Imaging findings in patients with axial spondyloarthritis presenting with recurrent fever attacks: data from the international AIDA network spondyloarthritis registry. Frontiers in Medicine. Published 15 September 2025. doi: 10.3389/fmed.2025.1662890

Vitale A, Sbalchiero J, Caggiano V, et al. Development and implementation of the International AIDA Network Castleman’s disease registry. Frontiers in Medicine. Published 3 September 2025. doi: 10.3389/fmed.2025.1579182

Sota J, Mejía-Salgado G, Guerriero S, et al. Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry. Frontiers in Medicine. Published 30 July 2025. doi: 10.3389/fmed.2025.1609613

Sota J, Breda L, Paroli MP, et al. Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders. British Journal of Ophthalmology. Published Online First: 24 May 2025. doi: 10.1136/bjo-2025-327410

Gaggiano C, de-la-Torre A, Guerriero S, et al. Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis: Data From the AIDA Network Uveitis Registry. Clinical & Experimental Ophthalmology. Published 04 April 2025. doi: doi.org/10.1111/ceo.14534

Vitale A, Caggiano V, Sbalchiero J, et al. Predictors of proteinuria, amyloidosis and kidney failure in familial Mediterranean fever: data from the International AIDA Network Registry. Rheumatology. Published 02 April 2025. doi: 10.1093/rheumatology/keaf181

Vitale A, Leone F, Caggiano V, et al. Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network. Frontiers in Pharmacology. Published 07 March 2025. doi: 10.3389/fphar.2025.1539756

Vitale A, Caggiano V, Leone F, et al. Efficacy and safety profile of biotechnological agents and Janus kinase inhibitors in VEXAS syndrome: data from the international AIDA Network VEXAS registry. Frontiers in Pharmacology. Published 19 February 2025. doi: 10.3389/fphar.2025.1462254

Caggiano V, Vitale A, Hinojosa-Azaloa A, et al. Development and implementation of the international AIDA network spondyloarthritis registry. Frontiers in Medicine. Published 14 February 2025. doi: 10.3389/fmed.2025.1509357

Ruscitti P, Vitale A, Di Cola I, et al. The clinical assessment of lng involvement in patients with Still's disease, result from the multicentre international AIDA Network Still's Disease Registry. Rheumatology. Online ahead of print, 20 January 2025. doi: 10.1093/rheumatology/keaf021

Sota J, Ragab G, AlMaglouth I, et al. Influence of gender on Behçet’s Disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet’s Disease Registry. Joint Bone Spine. Online ahead of print 15 November 2024. doi: 10.1016/j.jbspin.2024.105819

Ruscitti P, Di Cola I, Vitale A, et al. The evaluation of myocarditis in patients with Still’s disease; clinical findings from the multicentre international AIDA Network Still’s Disease Registry. The Journal of Rheumatology. Published 1 November 2024. doi: 10.3899/jrheum.2024-0683

Vitale A, Caggiano V, Martín-Nares E, et al. Dry eye disease and spondyloarthritis: expanding the spectrum of systemic inflammatory disorders associated with ocular surface disease. Data from the international AIDA Network Spondyloarthritis Registry. Frontiers in Medicine. Published 17 September 2024. doi: 10.3389/fmed.2024.1422307

Vitale A, Palacios-Olid J, Caggiano V, Ragab G, Hernández-Rodríguez J, et al. Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries. Frontiers in Medicine. Published 23 August 2024. doi: 10.3389/fmed.2024.1439338

Sota J, Guerriero S, Lopalco G, et al. Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders. Ocular Immunology and Inflammation. Published 17 May 2024. doi: 10.1080/09273948.2024.2346815

Ruscitti P, Masedu F, Vitale A, Caggiano V, et al. The Systemic Score May Identify Life-Threatening Evolution in Still Disease: Data from the GIRRCS AOSD-Study Group and the AIDA Network Still Disease Registry. Arthritis & Rheumatology. Published 15 May 2024. doi: 10.1002/art.42845

Vitale A, Caggiano V, Tufan A, et al. Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries. Frontiers in Immunology. Published 10 May 2024. doi: 10.3389/fimmu.2024.1397890

Gaggiano C, Tufan A, Guerriero S, et al. Ocular Manifestations in Juvenile Behçet’s Disease: A Registry-Based Analysis from the AIDA Network. Ophthalmology and Therapy. Published 30 march 2024. doi: 10.1007/s40123-024-00916-z

Vitale A, Caggiano V, Martin-Nares E, et al. Orbital/ocular inflammatory involvement in VEXAS syndrome: Data from the international AIDA network VEXAS registry. Seminars in Arthritis and Rheumatism. Published 18 march 2024. doi: 10.1016/j.semarthrit.2024.152430

Tarsia M, Vitale A, Gaggiano C, et al. Effectiveness and Safety of Biosimilars in Pediatric Non-infectious Uveitis: Real-Life Data from the International AIDA Network Uveitis Registry. Ophthalmology and Therapy. Published 11 january 2024. doi: 10.1007/s40123-023-00863-1

Vitale A, Caggiano V, Sfikakis PP, et al. Efficacy of canakinumab in patients with Still’s disease across different lines of biologic therapy: real-life data from the International AIDA Network Registry for Still’s Disease. Frontiers in medicine, Sec. Rheumatology. Published 12 December 2023. doi: 10.3389/fmed.2023.1256243

Vitale A, Caggiano V, Lopalco G, et al. Still’s disease continuum from childhood to elderly: data from the international AIDA Network Still’s disease registry. RMD Open. Published 1 December 2023. doi: 10.1136/rmdopen-2023-003578

Ruscitti P, Masedu F, Vitale A, et al. Derivation and validation of four patient clusters in Still’s disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry. RMD Open. Published 20 November 2023. doi: 10.1136/rmdopen-2023-003419

Gaggiano C, Gupta V, Agrawal R, et al. Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network. Ophthalmology and Therapy. Published 4 November 2023. doi: 10.1007/s40123-023-00839-1

Triggianese P, Vitale A, Lopalco G, et al. Clinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry. Intern Emerg Med. Published online ahead of print, 12 October 2023. doi: 10.1007/s11739-023-03408-3

D'Onghia M, Cinotti E, Cartocci A, et al. Unfolding dermatologic spectrum of Behçet's disease in Italy: real-life data from the International AIDA Network Behçet's disease Registry. Intern Emerg Med. Published online ahead of print, 6 October 2023. doi: 10.1007/s11739-023-03410-9

Ruscitti P, Sota J, Vitale A, et al. The administration of methotrexate in patients with Still’s disease, “real-life” findings from AIDA Network Still Disease Registry. Seminars in Arthritis and Rheumatism. Published 21 July 2023. doi: 10.1016/j.semarthrit.2023.152244

Gaggiano C, Del Bianco A, Sota J, et al. A patient-driven registry on Behçet’s disease: the AIDA for patients pilot project. Frontiers in medicine, Sec. Rheumatology. Published 16 June 2023. doi: 10.3389/fmed.2023.1188021

Vitale A, Della Casa F, Guerriero S, et al. Efficacy and safety of Adalimumab in pediatric noninfectious non-anterior uveitis: real-life experience from the International AIDA Network Uveitis Registry. Ophthalmol Ther. Published 11 May 2023. doi: 10.1007/s40123-023-00712-1

Vitale A, Caggiano V, Silva I, et. al. Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs). Frontiers in medicine, Sec. Rheumatology. Published 30 May 2023. doi: 10.3389/fmed.2023.1195995

Gaggiano C, Maselli A, Sfikakis PP, et al. Musculoskeletal manifestations in children with Behçet’s syndrome: data from the AIDA Network Behçet’s Syndrome Registry. Intern Emerg Med. Published 07 March 2023. doi: 10.1007/s11739-023-03215-w

La Torre F, Sota J, Insalaco A, et al. Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: A multicenter study from the AIDA Network PFAPA syndrome registry. Frontiers in medicine, Sec. Rheumatology. Published 13 February 2023. doi: 10.3389/fmed.2023.1105605

Vitale A, Caggiano V, Maggio MC, et al. Canakinumab as first-line biological therapy in Still’s disease and differences between the systemic and the chronic-articular courses: Real-life experience from the international AIDA registry. Frontiers in medicine, Sec. Rheumatology. Published 22 December 2022. doi.org/10.3389/fmed.2022.1071732

Gaggiano C, Vitale A, Tufan A, et al. The Autoinflammatory Diseases Alliance Registry of monogenic autoinflammatory diseases. Frontiers in medicine, Sec. Rheumatology. Published 09 September 2022. doi:10.3389/fmed.2022.980679

Sota J, Vitale A, Lopalco G, et al. Efficacy and safety of tocilizumab in adult-onset Still's disease: Real-life experience from the international AIDA registry. Seminars in Arthritis and Rheumatism. Published 30 August 2022. doi:10.1016/j.semarthrit.2022.152089

Della Casa F, Vitale A, Cattalini M, et al. Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome. Front. Pediatr., Sec. Pediatric Immunology. Published 22 July 2022. doi:10.3389/fped.2022.930305

Vitale A, Della Casa F, Ragab G, et al. Development and implementation of the AIDA International Registry for patients with Behçet’s disease. Internal and Emergency Medicine. Published 14 July 2022. doi:10.1007/s11739-022-03038-1

Vitale A, Caggiano V, Della Casa F, et al. Development and Implementation of the AIDA International Registry for Patients With VEXAS Syndrome. Frontiers in medicine, Sec. Rheumatology. Published 11 July 2022. doi:10.3389/fmed.2022.926500

Sota J, Vitale A, Więsik-Szewczyk E, et al. Development and implementation of the AIDA international registry for patients with Schnitzler's syndrome. Frontiers in medicine, Sec. Rheumatology. Published 18 July 2022. doi:10.3389/fmed.2022.931189

Della Casa F, Vitale A, Lopalco G, et al. Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases. Frontiers in medicine, Sec. Rheumatology. Published 10 June 2022. doi:10.3389/fmed.2022.908501

Vitale A, Della Casa F, Lopalco G, et al. Development and Implementation of the AIDA International Registry for Patients With Still's Disease. Frontiers in medicine, Sec. Rheumatology. Published 07 April 2022. doi:10.3389/fmed.2022.878797

Della Casa F, Vitale A, Guerrieri S, et al. Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Uveitis. Ophthalmology and Therapy, 11, 899-911 (2022). Published 31 January 2022. doi:10.1007/s40123-022-00459-1

Della Casa F, Vitale A, Pereira RM, et al. Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Scleritis. Ophthalmology and Therapy, 11, 887-897 (2022). Published 29 January 2022. doi:10.1007/s40123-022-00466-2

Gaggiano C, Rigante D, Hernández-Rodríguez J, et al. Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: a multicenter observational study from the AIDA Network. Therapeutic Advances in Musculoskeletal Disease. Published 9 September 2021. doi:10.1177/1759720X211037178

Vitale A, Obici L, Cattalini M, et. al. Biotechnological Agents for Patients With Tumor Necrosis Factor Receptor Associated Periodic Syndrome - Therapeutic Outcome and Predictors of Response: Real-Life Data From the AIDA Network. Front. Med., 2021. Published 8 July 2021. doi:10.3389/fmed.2021.668173

Sota J, Rigante D, Cimaz R, et. al. Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry. Rheumatology, 2021. Published 07 May 2021. doi:10.1093/rheumatology/keab419

Sota J, Rigante D, Lopalco G, et al. Clinical profile and evolution of patients with juvenile-onset Behçet’s syndrome over a 25-year period: insights from the AIDA network. Internal and Emergency Medicine 16, 2163-2171 (2021). Published 09 April 2021. doi:10.1007/s11739-021-02725-9

Gaggiano C, Vitale A, Obici L, et al. Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor-Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA Network. Mediators Inflamm. 2020. Published 7 Aug 2020. doi:10.1155/2020/8562485

Vitale A, Sota J, Obici L, et al. Role of Colchicine Treatment in Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS): Real-Life Data from the AIDA Network. Mediators Inflamm. 2020. Published 27 May 2020. doi:10.1155/2020/1936960