Research
Risk for cancer development in familial Mediterranean fever and associated predisposing factors
An ambidirectional cohort study from the international AIDA Network registries explores the relationship between inflammation and cancer development, focusing on FMF.
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This new groundbreaking study has explored cancer risk among patients with Familial Mediterranean Fever (FMF) compared to those with fibromyalgia, Still’s disease, and Behçet’s disease. By leveraging the extensive data from the international AIDA Network - registries dedicated to monogenic autoinflammatory diseases, Still’s disease, and Behçet’s disease - the study results provided clear and compelling insights into this intriguing issue. In particular, the study reveals that Caucasian FMF patients generally face a reduced cancer risk and, when cancer does occur, it is more prevalent among patients with severe FMF phenotype and those who have inadequate responses to colchicine, the standard of care in FMF. The large-scale data provided by the network was crucial in clarifying these findings and highlighting the nuances of cancer risk in FMF patients.